About 0.8 to 1.2 billion people globally have ascariasis, with the most heavily affected populations being in sub-Saharan Africa, Latin America, and Asia.[1][10][11] This makes ascariasis the most common form of soil-transmitted helminthiasis.[10] As of 2010 it caused about 2,700 deaths a year, down from 3,400 in 1990.[12] Another type of Ascaris infects pigs.[1] Ascariasis is classified as a neglected tropical disease.[6]

This article is about the infection. For the organism, see Ascaris. Not to be confused with Acariasis a mite infection. Ascariasis Ascaris infection in X-ray image- Duedenal worms - in the first portion of the bowel after the stomach (South Africa) (16238958958).jpg High number of ascaris worms – visible as black tangled mass – are filling the duodenum, the first portion of the bowel after the stomach, of this South African patient (X-ray image with barium as contrast medium) Specialty Infectious disease Symptoms Abdominal swelling, abdominal pain, diarrhea, shortness of breath[1] Causes Eating Ascaris eggs[2] Prevention Improved sanitation, handwashing[1] Medication Albendazole, mebendazole, levamisole, pyrantel pamoate[2] Frequency 762 million (2015)[3] Deaths 2,700 (2015)[4] [edit on Wikidata] Ascariasis is a disease caused by the parasitic roundworm Ascaris lumbricoides.[1] Infections have no symptoms in more than 85% of cases, especially if the number of worms is small.[1] Symptoms increase with the number of worms present and may include shortness of breath and fever in the beginning of the disease.[1] These may be followed by symptoms of abdominal swelling, abdominal pain, and diarrhea.[1] Children are most commonly affected, and in this age group the infection may also cause poor weight gain, malnutrition, and learning problems.[1][2][5] Infection occurs by eating food or drink contaminated with Ascaris eggs from feces.[2] The eggs hatch in the intestines, burrow through the gut wall, and migrate to the lungs via the blood.[2] There they break into the alveoli and pass up the trachea, where they are coughed up and swallowed.[2] The larvae then pass through the stomach for a second time into the intestine, where they become adult worms.[2] It is a type of soil-transmitted helminthiasis and part of a group of diseases called helminthiases.[6] Prevention is by improved sanitation, which includes improving access to toilets and proper disposal of feces.[1][7] Handwashing with soap appears protective.[8] In areas where more than 20% of the population is affected, treating everyone at regular intervals is recommended.[1] Reoccurring infections are common.[2][9] There is no vaccine.[2] Treatments recommended by the World Health Organization are the medications albendazole, mebendazole, levamisole, or pyrantel pamoate.[2] Other effective agents include tribendimidine and nitazoxanide.[2] About 0.8 to 1.2 billion people globally have ascariasis, with the most heavily affected populations being in sub-Saharan Africa, Latin America, and Asia.[1][10][11] This makes ascariasis the most common form of soil-transmitted helminthiasis.[10] As of 2010 it caused about 2,700 deaths a year, down from 3,400 in 1990.[12] Another type of Ascaris infects pigs.[1] Ascariasis is classified as a neglected tropical disease.[6] Contents [hide] 1 Signs and symptoms 1.1 Migrating larvae 1.2 Intestinal blockage 1.3 Bowel obstruction 1.4 Allergies 1.5 Malnutrition 1.6 Others 2 Cause 2.1 Transmission 2.2 Lifecycle 3 Diagnosis 4 Mechanism 5 Prevention 6 Treatment 6.1 Medications 6.2 Surgery 7 Prognosis 8 Epidemiology 8.1 Regions 8.2 Infection estimates 8.3 Deaths 9 Research 10 Other animals 11 Miscellaneous 12 References 13 External links Signs and symptoms[edit] Further information: Helminthiasis § Signs and symptoms Most people who are infected with only a small number of worms have no symptoms. It is common to find that most people are infected by a small number of worms, while a small number of people are heavily infected, something that is characteristic of many worm infections.[1][13] Clinical features depend on the affected body site. Migrating larvae[edit] As larval stages travel through the body, they may cause visceral damage, peritonitis and inflammation, enlargement of the liver or spleen, and an inflammation of the lungs. Pulmonary manifestations take place during larval migration and may present as Loeffler's syndrome, a transient respiratory illness associated with blood eosinophilia and pulmonary infiltrates with radiographic shadowing.[14] Intestinal blockage[edit] Piece of intestine, blocked by worms, surgically removed from a 3-year-old boy in South Africa.[15] The worms can occasionally cause intestinal blockage when large numbers get tangled into a bolus or they may migrate from the small intestine, which may require surgery. More than 796 A. lumbricoides worms weighing up to 550 g [19 ounces] were recovered at autopsy from a 2-year-old South African girl. The worms had caused torsion and gangrene of the ileum, which was interpreted as the cause of death.[16] Bowel obstruction[edit] Bowel obstruction may occur in up to 0.2 per 1000 per year.[1] A worm may block the ampulla of Vater, or go into the main pancreatic duct, resulting in acute pancreatitis with raised serum levels of amylase and lipase. Occasionally, a worm can travel through the billiary tree and even into the gallbladder, causing acute cholangitis or acute cholecystitis. Allergies[edit] Ascariasis may result in allergies to shrimp and dustmites due to the shared antigen, tropomyosin; this has not been confirmed in the laboratory.[17][18] Malnutrition[edit] The worms in the intestine may cause malabsorption and anorexia which contribute to malnutrition.[19] The malabsorption may be due to a loss of brush border enzymes, erosion and flattening of the villi, and inflammation of the lamina propria.[20] Others[edit] Ascaris have an aversion to some general anesthetics and may exit the body, sometimes through the mouth, when an infected individual is put under general anesthesia.[21] Cause[edit] Ascaris life cycle: Adult worms (1) live in the lumen of the small intestine. A female may produce approximately 200,000 eggs per day, which are passed with the feces (2). Unfertilized eggs may be ingested but are not infective. Fertile eggs embryonate and become infective after 18 days to several weeks (3), depending on the environmental conditions (optimum: moist, warm, shaded soil). After infective eggs are swallowed (4), the larvae hatch (5), invade the intestinal mucosa and are carried via the portal, then systemic circulation and/or lymphatics to the lungs . The larvae mature further in the lungs (6) (10 to 14 days), penetrate the alveolar walls, ascend the bronchial tree to the throat, and are swallowed (7). Upon reaching the small intestine, they develop into adult worms (8). Between 2 and 3 months are required from ingestion of the infective eggs to oviposition by the adult female. Adult worms can live 1 to 2 years. Transmission[edit] The source of infection is from objects which have been contaminated with fecal matter containing eggs.[2] Ingestion of infective eggs from soil contaminated with human feces or contaminated vegetables and water is the primary route of infection. Infectious eggs may occur on other objects such as hands, money and furniture.[2] Transmission from human to human by direct contact is impossible.[22] Transmission comes through municipal recycling of wastewater into crop fields. This is quite common in emerging industrial economies and poses serious risks for local crop sales and exports of contaminated vegetables. A 1986 outbreak of ascariasis in Italy was traced to irresponsible wastewater recycling used to grow Balkan vegetable exports.[23] The number of ova (eggs) in sewage or in crops that were irrigated with raw or partially treated sewage, is a measure of the degree of ascariasis incidence. For example: In a study published in 1992, municipal wastewater in Riyadh, Saudi Arabia detected over 100 eggs per litre of wastewater[24] and in Czechoslovakia was as high as 240–1050 eggs per litre.[25] In one field study in Marrakech, Morocco, where raw sewage is used to fertilize crop fields, Ascaris eggs were detected at the rate of 0.18 eggs/kg in potatoes, 0.27 eggs/kg in turnip, 4.63 eggs/kg in mint, 0.7 eggs/kg in carrots, and 1.64 eggs/kg in radish.[26] A similar study in the same area showed that 73% of children working on these farms were infected with helminths, particularly Ascaris, probably as a result of exposure to the raw sewage. The larva of Ascaris lumbricoides developing in the egg Ascaris lumbricoides adult worms (with measuring tape for scale) Ascaris lumbricoides adult worms Ascaris egg, incubation process: The Ascaris egg incubation process consists in placing the egg in a controlled environment, at 26 °C during 28 days, in acidic conditions. This process allows for evaluation of an egg to determine if it is viable or not, by watching the bipartition of the nucleus, and the growth of the larva. Lifecycle[edit] The first appearance of eggs in stools is 60–70 days. In larval ascariasis, symptoms occur 4–16 days after infection. The final symptoms are gastrointestinal discomfort, colic and vomiting, fever, and observation of live worms in stools. Some patients may have pulmonary symptoms or neurological disorders during migration of the larvae. There are generally few or no symptoms. A bolus of worms may obstruct the intestine; migrating larvae may cause pneumonitis and eosinophilia. Adult worms have a lifespan of 1–2 years which means that individuals may be infected all their lives as worms die and new worms are acquired.[13] Eggs can survive potentially for 15 years and a single worm may produce 200,000 eggs a day.[2] They maintain their position by swimming against the intestinal flow.[27] Diagnosis[edit] Most diagnoses are made by identifying the appearance of the worm or eggs in feces. Due to the large quantity of eggs laid, physicians can diagnose using only one or two fecal smears.[citation needed] The diagnosis is usually incidental when the host passes a worm in the stool or vomit. The eggs can be seen in a smear of fresh feces examined on a glass slide under a microscope and there are various techniques to concentrate them first or increase their visibility, such as the ether sedimentation method or the Kato technique. The eggs have a characteristic shape: they are oval with a thick, mamillated shell (covered with rounded mounds or lumps), measuring 35-50 micrometer in diameter and 40-70 in length. During pulmonary disease, larvae may be found in fluids aspirated from the lungs. White blood cells counts may demonstrate peripheral eosinophilia; this is common in many parasitic infections and is not specific to ascariasis. On X-ray, 15–35 cm long filling defects, sometimes with whirled appearance (bolus of worms). Mechanism[edit] Ascaris takes most of its nutrients from the partially digested host food in the intestine. There is some evidence that it can secrete anti-enzymes, presumably to protect itself from digestion by the hosts' enzymes. Children are often more severely affected.[1] Prevention[edit] Prevention is by improved access to sanitation which includes the use of properly functioning and clean toilets by all community members as one important aspect.[1] Handwashing with soap may be protective; however, there is no evidence it affects the severity of disease.[8] Eliminating the use of untreated human faeces as fertilizer is also important. In areas where more than 20% of the population is affected treating everyone is recommended.[1] This has a cost of about 2 to 3 cents per person per treatment.[1] This is known as mass drug administration and is often carried out among school-age children.[28] For this purpose, broad-spectrum benzimidazoles such as mebendazole and albendazole are the drugs of choice recommended by WHO.[29] Treatment[edit] Further information: Helminthiasis § Treatment Medications[edit] Medications that are used to kill roundworms are called ascaricides. Those recommended by the World Health Organization for ascariasis are: albendazole, mebendazole, levamisole and pyrantel pamoate.[2] Other effective agents include tribendimidine and nitazoxanide.[2] Pyrantel pamoate may induce intestinal obstruction in a heavy worm load. Albendazole is contraindicated during pregnancy and children under two years of age. Thiabendazole may cause migration of the worm into the esophagus, so it is usually combined with piperazine. Piperazine is a flaccid paralyzing agent that blocks the response of Ascaris muscle to acetylcholine, which immobilizes the worm. It prevents migration when treatment is accomplished with weak drugs such as thiabendazole. If used by itself, it causes the worm to be passed out in the feces and may be used when worms have caused blockage of the intestine or the biliary duct. Corticosteroids can treat some of the symptoms, such as inflammation. Other medications[edit] Hexylresorcinol effective in single dose[30] Santonin, more toxic than hexylresorcinol[30] and often only partly effective.[31] Oil of chenopodium, more toxic than hexylresorcinol[30] Surgery[edit] In some cases with severe infestation the worms may cause bowel obstruction, requiring emergency surgery.[32] The bowel obstruction may be due to all the worms or twisting of the bowel.[32] During the surgery the worms may be manually removed.[32] Prognosis[edit] It is rare for the infections to be life-threatening.[1] Epidemiology[edit] Ascariasis deaths per million persons in 2012 0-0 1-1 2-2 Disability-adjusted life year for ascariasis per 100,000 inhabitants in 2004. no data less than 10 10-20 20-30 30-40 40-50 50-60 60-80 80-100 100-120 120-140 140-150 more than 150 Regions[edit] Ascariasis is common in Africa and in Southeast Asia. It also occurs in the United States including Gulf Coast.[citation needed] Infection estimates[edit] Roughly 0.8-1.3 billion individuals are infected with this intestinal worm, primarily in Africa and Asia.[1][2][11] About 120 to 220 million of these cases are symptomatic.[1] One study indicated that the prevalence of ascariasis in the United States at about 4 million (2%).[citation needed] Deaths[edit] As of 2010 Ascariasis caused about 2,700 directly attributable deaths, down from 3,400 in 1990.[12] The indirectly attributable deaths due to the malnutrition link may be much higher. Research[edit] There are two animal models, the mouse and pig, used in studying Ascaris infection.[33][34] Other animals[edit] Infections in pigs leads to poor weight gain and thus financial losses for the farmer.[1] In pigs the infection is due to Ascaris suum.[1] In horses and other equines, the equine roundworm is Parascaris equorum and the parasites are colloquially called Ascarids. A problem for young animals more than for mature ones, clinical signs include unthriftiness, potbelly, rough hair coat, and slow growth.[35] Miscellaneous[edit]